TO REMEMBER WHERE MELANIN PIGMENT IS FOUND REMEMBER........... CAMS

TO REMEMBER WHERE MELANIN PIGMENT IS FOUND REMEMBER...........
CAMS

1. CHOROID OF EYE
2. ADRENAL MEDULLA
3. MENINGES
4. SKIN..

MORE INFORMATION..........

1. SYNTHESIZED IN MELANOCYTES AND D4ENDRITIC CELLS

2. MELANOCYTES POSSESES TYROSINASE

3. DETECTED BY INCUBATION OF TISSUE SECTION IN DOPA
HYPER PIGMENTATION

ADDISON DISEASE AREA TO LIGHT AND BUCCAL MUCOSA
CHLOASMA FACE, NIPPLES, GENITALIA
CHRONIC ARSENICAL POISING RAIN DROP PIGMENTATION
CAFE AU LAIT PATCHES IN ALBRIGHT SYNDROME
DERMATOPATHETIC LYMPHADENTICS MELANIN DEPOSITION IN MACROPHAGES OF LYMPH NODES
LENTIGO
MELOTIC TUMUOR

Barter's syndrome , Anemia (normocytic) , Herpes I and II

Barter's syndrome: pathogenesis, major sign

Barter: "In exchange for giving away Na+,K+,Cl-, you can drop the blood pressure".

Anemia (normocytic): causes               ABCD:

Acute blood loss
Bone marrow failure
Chronic disease
Destruction (hemolysis)

Herpes I and II: lab findings.

She's an odd chick: whenever she's in a restaurant, she always orders Her Peas and Cow dry.
Herpes I and II have Cowdry Type A inclusion bodies

Calculi , Whipple's disease , Cerebral palsy

Calculi: types                 CAlCUli:

Calcium
Ammonium magnesium phosphate
Cystine
Uric acid

Whipple's disease: full features                    WHIPPLES:

Weight loss
Hyperpigmentation of skin
Infection with tropheryma whippelii
PAS positive granules in macrophage
Polyarthritis
Lymphadenopathy
Enteric involvement
Steatorrhea

Cerebral palsy: general features                    PALSY:

Paresis
Ataxia
Lagging motor development
Spasticity
Young

Hypokalaemia , Lung cancer , IBD

Hypokalaemia: clinical features                      TIMID CHIMP:

Tetany
Increases paralytic ileus (aggravates)
Muscle weakness
Increases possibility of hepatic encephalopathy
Digoxin toxicity
Cardiac arrythmias
Hypotonia
Increases P-R interval, T wave and prominent U wave
Muscle cramps
Polyuria

Lung cancer: presentation                  ABCDE:

Snowball turned to Avalanche
Blood: hemoptysis
Cough
Distruption to airway in bronchus-->pneumonia
wheezing

IBD: extraintestinal manifestations      "Left intestine to sail the SEAS of the rest of the body":

Skin manifestations: erythema nodosum, pyoderma gangrenosum
Eye inflammation: iritis, episcleritis
Arthritis
Sclerosing cholangitis

Parkinson's symptoms , Thrombus , Pick's disease

Parkinson's symptoms                   RATS 

Rigitidy (cogwheel)
Akinesia
Tremor (resting)
Shuffling gate

Thrombus: possible fates                  DOPE:

Dissolution
Organization & repair
Propagation
Embolization

Pick's disease: features                  PICK: Progressive degeneration of neurons
Intracytoplasmic Pick bodies
Cortical atrophy
Knife edge gyri

Portal hypertension

Portal hypertension: features               ABCDE: 

Ascites
Bleeding (haematemesis, piles)
Caput medusae
Diminished liver
Enlarged spleen

Cushing syndrome                     CUSHING:

Central obesity/ Cervical fat pads/ Collagen fiber weakness/ Comedones (acne)
Urinary free corisol and glucose increase
Striae/ Suppressed immunity
Hypercortisolism/ Hypertension/ Hyperglycemia/ Hirsutism
Iatrogenic (Increased administration of corticosteroids)
Noniatrogenic (Neoplasms)
Glucose intolerance/ Growth retardation

Duchenne vs. Becker Muscular Dystrophy 

Duchenne Muscular Dystrophy (DMD) : Doesn't Make Dystrophin.
Becker Muscular Dystrophy (BMD): Badly Made Dystrophin (a truncated protein).

Thyroid carcinoma: frequency                "Please Feel My A$$": 

In order of most frequent to least frequent, and in order from least aggressive to most aggressive:
Papillary carcinoma
Follicular carcinoma
Medullary thyroid carcinoma
Anaplastic carcinoma